Morphological remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography

Summary: Coxiella burnetii is an obligate zoonotic bacterium that targets macrophages causing a disease called Q fever.It has a biphasic developmental life cycle where the extracellular and metabolically inactive small cell variant (SCV) transforms inside the host into the vegetative large cell variant (LCV).However, details about the morphological

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Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State

Abstract Despite substantial effort devoted in the history of supramolecular chemistry, synthetic supramolecular systems still lag behind biomolecular systems in terms of complexity and functionality.This is because biomolecular systems function in a multicomponent molecular network under out-of-equilibrium conditions.Here we report two-component s

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