HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity.This highly infectious mechanism is orchestrated by different cellular HAND SOAP targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles.Dendritic cells (DCs) are the most potent antigen presenting cells that initiate anti
Morphological remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography
Summary: Coxiella burnetii is an obligate zoonotic bacterium that targets macrophages causing a disease called Q fever.It has a biphasic developmental life cycle where the extracellular and metabolically inactive small cell variant (SCV) transforms inside the host into the vegetative large cell variant (LCV).However, details about the morphological
"Innovation ecosystems for youth agrifood entrepreneurship in the Mediterranean region"
This paper is the outcome of a reflection on the MIP report 2020, a collection of information and data used to describe the scenario on youth innovation and entrepreneurship in agrifood sector in Mediterranean countries.In particular, it highlights the need to study innovation in Mediterranean regions HAND SOAP under the lens of social and institut
Not Home Alone: Leveraging Telehealth and Informatics to Create a Lean Model for COVID-19 Patient Home Care
In response to the emerging COVID-19 public health emergency in March 2020, the Medical University of South Carolina rapidly implemented an analytics-enhanced remote patient monitoring (RPM) program with state-wide reach for SARS-CoV-2-positive patients.Patient-reported data and other analytics were used to prioritize the sickest patients for conta
Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
Abstract Despite substantial effort devoted in the history of supramolecular chemistry, synthetic supramolecular systems still lag behind biomolecular systems in terms of complexity and functionality.This is because biomolecular systems function in a multicomponent molecular network under out-of-equilibrium conditions.Here we report two-component s